Phenolic constituents from twigs of Aleurites fordii and their biological activities

• Kyoung Jin Park,
• Won Se Suh,
• Da Hye Yoon,
• Chung Sub Kim,
• Sun Yeou Kim and
• Kang Ro Lee

Beilstein J. Org. Chem. 2021, 17, 2329–2339, doi:10.3762/bjoc.17.151

• fordii; antineuroinflammation; Euphorbiaceae; neolignan glycoside; neuroprotective activity; phenolic compound; Introduction Aleurites fordii Hemsl. (= Vernicia fordii Hemsl., Euphorbiaceae), known as tung oil tree, is widely distributed throughout Northeast Asia [1]. The fruits, leaves, and roots of

Synthesis of spirocyclic scaffolds using hypervalent iodine reagents

• Fateh V. Singh,
• Priyanka B. Kole,
• Saeesh R. Mangaonkar and
• Samata E. Shetgaonkar

Beilstein J. Org. Chem. 2018, 14, 1778–1805, doi:10.3762/bjoc.14.152

• PIDA (15) as an electrophile in hexafluroisopropanol solvent. The p-substituted phenolic compound 48 was used as starting material for the construction of spirolactam 49 in 69% yield (Scheme 15). This is an important intermediate in the synthesis of various naturally occurring alkaloids such as

• same research group [104]. In this report, spirocyclic oxazoline 93 was prepared by starting from para-substituted phenolic compound 92 under the reaction conditions mentioned in Scheme 32 (Scheme 33). In 2002, Honda and co-workers [105] reported the synthesis of naturally occurring (−)-TAN1251A (95

• ) employing an oxidation of phenols via an dearomatization process. In this report, para-substituted phenolic compound 48 was cyclized to spirocyclic lactam 49 using PIDA (15) as an electrophile. The spirocyclic compound 49 was achieved in 69% yield (Scheme 34). Additionally, synthesized spirocyclic compound

Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry

• Katharina Hiebler,
• Georg J. Lichtenegger,
• Manuel C. Maier,
• Eun Sung Park,
• Renie Gonzales-Groom,
• Bernard P. Binks and
• Heidrun Gruber-Woelfler

Beilstein J. Org. Chem. 2018, 14, 648–658, doi:10.3762/bjoc.14.52

• interface populated by catalyst particles. They deposited metallic Pd onto carbon nanotube–inorganic oxide hybrid nanoparticles and used them in emulsions for the hydrodeoxygenation of a phenolic compound and the hydrogenation and etherification of an aldehyde. The advantages of such a system include a high

Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view

• Qiu Sun,
• Jörg Heilmann and
• Burkhard König

Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28

• , acylphloroglucinols, quinolone-substituted phenols and 4-amino-2-sulfanylphenol derivatives are discussed. Some important aspects of the described pharmacological activities of the compounds are summarized in Table 3. Review 4-Hydroxybenzyl alcohol 4-Hydroxybenzyl alcohol (HBA, 1) (Figure 1) is a well-known phenolic

• compound found in plants and has been isolated from, for example, the flowers of carrot (Daucus carrota L., Apiaceae). In 2007, Park and co-workers [15] found no change in the vascular density in the chick chorioallantoic membrane (CAM) assay in the presence of HBA, indicating that HBA had no influence on

Trogopterins A–C: Three new neolignans from feces of Trogopterus xanthipes

• Soyoon Baek,
• Xuikui Xia,
• Byung Sun Min,
• Chanil Park and
• Sang Hee Shim

Beilstein J. Org. Chem. 2014, 10, 2955–2962, doi:10.3762/bjoc.10.313

• fecal extracts led to the isolation of seven compounds including three new neolignans named trogopterins A–C (1–3). Here we describe the isolation, structure, and cytotoxic activities of compounds 1–3. Results and Discussion Seven compounds, including three neolignans (1–3), a phenolic compound 4, and

• new phenolic compound (trogopterin C) were isolated from the crude methanol extract of Trogopterus feces for the first time. The absolute configurations of compounds 1, 2, and 4 were determined by comparing CD spectra and optical rotations. The levels of cytotoxicity against three tumor cell lines (HL

Studies on polynuclear furoquinones. Part 1: Synthesis of tri- and tetra- cyclic furoquinones simulating BCD/ABCD ring system of furoquinone diterpenoids

• Faruk H. Shaik and
• Gandhi K. Kar

Beilstein J. Org. Chem. 2009, 5, No. 47, doi:10.3762/bjoc.5.47

• of aryl-furyl C–C bond via Suzuki reaction [35] and the generation of the quinone functionality by oxidation of a phenolic intermediate (Figure 2). Retrosynthesis of the molecule showed that the required phenolic compound can easily be achieved in 7–8 steps starting from 2-bromo-3,4-dihydro-1